The life-changing science behind longevity and medical nutrition therapies
At Prolon, science isn’t a tagline; it’s our DNA. Developed in collaboration with the Longevity Institute at USC and created by world-renowned longevity scientist Dr. Valter Longo, Prolon’s Fasting Mimicking Diet (FMD) has been validated through 25 years of research and 40+ clinical trials.
Supported by $48M in funding and validated by research with 18 leading institutions—including Stanford, Mayo Clinic, the University of Miami, and the University of Genoa—Prolon is the first and only patented nutrition program shown to support longevity through cellular renewal.
Founded by scientists and grounded in peer-reviewed evidence, Prolon brings biotech-grade rigor to everyday nutrition. It’s not a trend. It’s a proven intervention designed to help you live healthier, longer.
Most read articles and studies
Explore the research
With more than 40 clinical trials published in leading scientific and medical journals worldwide, Prolon’s impact is proven by some of the most rigorous nutrition research to date. Browse a selection of our studies below.
The FMD is the only nutrition program supported by preliminary data confirming autophagy activation in humans
+A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy
+Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk
+Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease: controlled trial
+Fasting-Mimicking-Diet does not reduce skeletal muscle function in healthy young adults: a randomized control trial
+A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
+The Effects of a Fasting Mimicking Diet on Skin Hydration, Skin Texture, and Skin Assessment: A Randomized Controlled Trial
+Fasting Mimicking Diet Cycles vs a Mediterranean Diet and Cardiometabolic Risk in Overweight and Obese Hypertensive Subjects: A Randomized Clinical Trial
+Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial
+Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality
+An Intermittent Fasting Mimicking Nutrition Bar Extends Physiologic Ketosis in Time Restricted Eating: A Randomized, Controlled, Parallel-Arm Study
+Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis
+Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan
+Fasting and cancer treatment in humans: A case series report
+Fasting-mimicking diet and hormone therapy induce breast cancer regression
+Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence
+Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology
+Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
+Prolonged Fasting reduces IGF-1/PKA to promote hematopoietic stem cell-based regeneration and reverse immunosuppression
+A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
+Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control.
+Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes
+From the pioneers in longevity science
Prolon is the only nutrition program patented for supporting longevity, healthspan, and protecting lean body mass through cellular rejuvenation.
25+
Years of scientific research
Decades of studies on longevity and nutrition
47
Clinical trials
Conducted with world-leading institutions
18
Leading research institutions
Including USC, Stanford, Mayo Clinic, and more
200+
Pending or issued patents
For optimizing longevity and healthspan
